BRAND / VENDOR: Merck

Merck, SML1046-5MG, CHIR99021

CATALOG NUMBER: SML1046-5MG

Prix régulier$0.99
/
Frais d'expédition calculés lors du passage à la caisse.
  • 99 en stock
  • En rupture de stock, expédition prochainement

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Product Description

CHIR99021 is an aminopyrimidine derivative. CHIR99021 promotes self-renewal potential of embryonic stem cells (ESCs) of mice by inhibiting glycogen synthase kinase-3 (GSK-3) activity and potentiates the upregulation of β-catenin and c-Myc functions. CHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor β (TGF-β), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines.

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