Thermo Fisher, 22307, Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester) Thermo Scientific Pierce Sulfo-EMCS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.
4 angstroms).
Features of Sulfo-EMCS:
•Reactive groups:sulfo-NHS esterandmaleimide
•Reactive towards: amino and sulfhydryl groups
• Sulfo-NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimide reacts with -SH groups at pH 6.
5-7.
5, forming stable thioether linkages
• Non-cleavable
• Water-soluble (compare toEMCS)
• Aliphatic spacer offers low potential for eliciting an immune responseProduct References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: No
Description: Sulfo-EMCS
Form: Powder
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 410.
33
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Maleimide, Sulfo-NHS Ester
Shipping Condition: Ambient
Solubility: Water
Spacer Arm Length: 9.
4 Å
Water Soluble: Yes
Chemical Reactivity: Amine-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Short (<10 Å)
Unit Size: Each