Thermo Fisher, 22335, DTME (dithiobismaleimidoethane)

DTME (dithiobismaleimidoethane) Thermo Scientific Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.
g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.
Features of DTME:
•Reactive groups:maleimide(both ends)
•Reactive towards:sulfhydryl groups
• Long (13.
3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
• Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
• Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agentProduct References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Description: DTME
Form: Solid
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 312.
36
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Maleimide
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 13.
3 Å
Water Soluble: No
Chemical Reactivity: Sulfhydryl-Sulfhydryl
Cleavable: By Thiols
Crosslinker Type: Homobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Medium (10 to 30 Å)
Unit Size: Each