BRAND / VENDOR: Thermo Fisher

Thermo Fisher, A39268, Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

CATALOG NUMBER: A39268

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Product Description

Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.
3 angstroms).
Features of Sulfo-SMCC, No-Weigh Format:
•Reactive groups:sulfo-NHS esterandmaleimide
•Reactive towards: amino and sulfhydryl groups
• Water-soluble (compare toSMCC), so crosslinking can be done in physiologic solutions
• High purity, crystalline reagent can be used to create high-purity maleimide-activated derivatives
• Cyclohexane bridge confers added stability to the maleimide group making Sulfo-SMCC the ideal crosslinking agent for maleimide activation of proteins. Maleimide groups are stable for 64 hours in 0.
1 M sodium phosphate buffer, pH 7 at 4°C.
Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC) is a non-cleavable and membrane impermeable crosslinker. It contains an amine-reactiveN-hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.
5-7.
5 to form stable thioether bonds. The maleimide groups of Sulfo-SMCC andSMCCare unusually stable up to pH 7.
5 because of the cyclohexane bridge in the spacer arm. Because it contains the hydrophilic sulfonyl moiety, Sulfo-SMCC is soluble up to ∼10 mM in water and many commonly used buffers, thus avoiding the use of organic solvents which may perturb protein structure.
Applications:
• Enzyme labeling of antibodies - both enzyme and antibody specificity can be preserved
• Create specific bioconjugates via one- or two-step crosslinking reactions
• Create sulfhydryl-reactive, maleimide-activated carrier proteins for coupling haptensSpecifications:Sulfo-SMCC is manufactured to the highest specifications to produce the most specific bioconjugates and maleimide-activated proteins, ensure the integrity of your data and to provide you with the highest degree of crosslinking consistency. Each lot of Sulfo-SMCC is tested to meet the following minimum specifications.
• Identity: IR scan shows only peaks characteristic of the structure and functional groups of Sulfo-SMCC crosslinker
• Purity: ≥ 90% by quantitative NMR (the highest standard for crosslinker purity)
• Solubility: ≥ 10 mg/mL in DI waterProduct References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: No
Description: Sulfo-SMCC
Form: Solid
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 436.
37
PEGylated: No
Product Line: No-Weigh™
Quantity: 10 x 2 mg
Reactive Moiety: Maleimide, Sulfo-NHS Ester
Shipping Condition: Ambient
Solubility: Water
Spacer Arm Length: 8.
3 Å
Water Soluble: Yes
Chemical Reactivity: Amine-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard, Single-use, Premium-grade
Product Type: Crosslinker
Spacer: Short (<10 Å)
Unit Size: Each

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