Cytiva, 17549803, MabSelect PrismA™ protein A chromatography resin

MabSelect PrismA, 1 L MabSelect PrismA™ resin is available for immediate delivery. MabSelect PrismA™ affinity chromatography resin has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein A-derived ligand. This allows future demands in mAb purification to be met, including processing of many bispecific antibodies. • Enhanced dynamic binding capacity allows high mass throughput of processed mAb per resin volume unit. • Excellent alkaline stability enables efficient cleaning and sanitization using 0.5–1.0 M NaOH for improved process economy, bioburden control, and robustness. • Covered by a comprehensive security of supply program, including dual sources of the agarose base matrix and protein A ligand. • The PrismA protein A ligand is also available in HiTrap Fibro™ and HiScreen Fibro™ PrismA chromatography units for ultrafast purification of mAbs. • Easily measure protein A leakage using the PrismA ELISA kit specifically designed for use with MabSelect PrismA™ resins. The enhanced alkaline stability of MabSelect PrismA™ also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest. For samples, contact your local sales representative or customer support. MabSelect PrismA™ protein A resin builds on the proven track record of MabSelect™ and MabSelect SuRe™ resins in downstream processing of monoclonal antibodies. Learn about ReadyToProcess MabSelect PrismA™ , prepacked HiScreen MabSelect PrismA™ , HiTrap MabSelect PrismA™ , PreDictor MabSelect PrismA™ or PreDictor Robocolumns MabSelect PrismA™ . Learn how Bispecific antibodies (BsAb) can be purified using protein A chromatography in only a single step. Learn about large scale column packing using MabSelect PrismA™ . Learn about reducing bioburden and sanitization of MabSelect PrismA™