Abcam, ab185214, Anti-Gbeta5 antibody [EPR14779(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Gbeta5 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14779(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gbeta5 also known as Guanine nucleotide-binding protein subunit beta-5 is a regulatory component of heterotrimeric G-proteins. It has an approximate mass of 37 kDa. Gbeta5 is expressed in multiple tissues with significant levels found in the brain and retina. Mechanically Gbeta5 acts as a modulator for signal transduction pathways partnering with the regulator of G-protein signaling (RGS) proteins to influence neuronal signaling processes.
Biological function summary
Gbeta5 functions as an integral part of the G-protein coupled receptor (GPCR) signaling system. It forms stable complexes with RGS proteins particularly RGS6 RGS7 RGS9 and RGS11. These complexes regulate the deactivation of G-proteins impacting the timing and efficacy of signaling events. The Gbeta5 and RGS complexes contribute to the modulation of neurotransmitter release and synaptic plasticity critical in nervous system functionalities.
Pathways
Gbeta5 plays a significant role in neurotransmission pathways such as the dopaminergic and serotonergic pathways. Its activity is linked to the fine-tuning of neuronal signals by influencing cyclic AMP levels and Ca2+ channel activity. Gbeta5 interacts with proteins like RGS9 which is important in visual and dopaminergic signaling highlighting its importance in these specific pathways.
Mutations or dysregulation in Gbeta5 have associations with neurodegenerative conditions and mood disorders such as Alzheimer's disease and major depressive disorder. The dysregulated activity can lead to altered interaction with proteins like RGS7 and RGS9 affecting normal neuronal signaling and function which may contribute to the pathology of these conditions. Understanding Gbeta5’s role can provide insights into developing therapeutic strategies for these disorders.