Abcam, ab185574, Anti-CPTP antibody - N-terminal

Size: 100µL
Rabbit Polyclonal CPTP antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPTP aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CPTP aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q5TA50

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CPTP also known as ceramide-1-phosphate transfer protein is a specialized protein that facilitates the transfer of ceramide-1-phosphate (C1P) between membranes. CPTP has a molecular mass of approximately 25 kDa. You can find it widely expressed in tissues such as liver lung and kidney indicating its significant functional roles across different organ systems. Its structural characteristics make it a critical facilitator in the local distribution of lipids contributing to cellular lipid homeostasis.
Biological function summary
The transfer of C1P by CPTP plays an important role in various signaling pathways and cellular processes. While it's not a component of a larger complex CPTP functions independently to mediate the intermembrane transport of its lipid substrate. This activity influences processes such as cell proliferation inflammation and apoptosis. Through its interaction with C1P CPTP significantly impacts cellular responses to stress and external stimuli serving as a vital regulator of cell fate.
Pathways
CPTP and its associated lipid transport function integrate into essential biological routes such as the sphingolipid signaling pathway and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. In these pathways C1P collaborates with proteins like sphingosine kinases and cPLA2 to affect cellular responses. The transport activity of CPTP ensures the precise localization of C1P providing a fine-tuning mechanism necessary for maintaining pathway integrity and function.
Dysregulation of CPTP activity has been linked to conditions such as inflammatory diseases and metabolic disorders. Inflammatory processes might get disrupted with altered CPTP function due to its regulation of lipid mediators of inflammation. Additionally abnormal lipid signaling through proteins related to CPTP like cPLA2 may contribute to the pathogenesis of metabolic syndrome. Further understanding of CPTP's disease associations offers the potential for novel therapeutic targets to mitigate these conditions.