Abcam, ab251080, Anti-NXN/NRX antibody [EPR15177] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal NXN/NRX antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15177,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251080 is the carrier-free version of
ab191429
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NXN also known as nucleoredoxin or NRX is a redox-regulating protein that plays a role in cellular signaling. This protein weighs approximately 49 kDa and is expressed in a wide range of tissues including heart liver and lungs. It’s known for its function in controlling redox states within cells. NXN acts within the cytoplasm where it interacts with other proteins to influence various signaling pathways. Given its importance scientists often study NXN to understand how cells manage oxidative stress and maintain equilibrium.
Biological function summary
NXN acts as a thioredoxin-like protein that regulates the Wnt signaling pathway through its interaction with disheveled proteins. This protein is often involved in cellular processes by managing the balance between oxidative and reductive states critical for normal cellular function. NXN exists in cells as part of larger protein assemblies which allows it to control multiple signaling hubs within the cell. This ability makes NXN integral to the modulation of cellular responses and adaptation to changes in environmental conditions.
Pathways
NXN is influential in the Wnt and JNK signaling pathways. In the Wnt signaling pathway NXN influences cellular fate decisions by regulating the availability of disheveled proteins. It also interacts with components of the JNK signaling pathway which is involved in controlling apoptosis and stress responses. Proteins such as β-catenin and JNK3 are affected by NXN's function highlighting its extensive reach in cellular mechanism and signaling control.
NXN has links to cancer and neurodegenerative diseases. Dysregulation in NXN can lead to abnormal cell proliferation linking it to the development of tumors. Its involvement in oxidative stress also places it in connection with neurodegenerative disorders like Alzheimer's disease. In cancer its interaction with proteins like p53 highlights its role in maintaining genomic stability. In the context of neurodegeneration NXN's relationship with proteins such as β-amyloid illustrates its potential involvement in disease progression and pathology.