Merck, 14-933, ATM, active

Research area: CANCER Product Source: Recombinant, human FLAG-tagged ATM full length, expressed in a mammalian cell line. The Ataxia telangiectasia mutated protein (ATM) is a serine/threonine protein kinase primarily found in the nuclei of cells and plays a crucial role in cellular processes. It shows similarities with phosphatidylinositol-3′-kinases and possesses inherent protein kinase activity. Located on chromosome 11 (11q22-23), the ATM gene comprises 66 exons and codes for the ATM protein consisting of 3056 amino acids. The ATM protein is made up of various domains and belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) superfamily. ATM kinase forms inactive homodimers under normal conditions and is activated under stressful conditions like DNA structural changes, oxidative stress, nutrient deprivation, or hypoxia.