Sartorius, 96MU01-----11, Sartobind® mAb pack

Sartobind® mAb Pack contains Nano capsules with Sartobind® Rapid A, anion exchange, cation exchange and hydrophobic interaction chromatography membranes to try different combinations for your membrane based mAb purification.

Sartobind® Rapid A is a protein A membrane chromatography solution designed to increase the efficiency of antibody purification processes. This platform is well-suited for process intensification, reducing process times due to higher operational flow rates, while maintaining high binding capacities and minimizing back pressure. Altogether, Sartobind® Rapid A has the potential to substantially reduce the cost associated with the mAb capture step, particularly in process development and production of material for early clinical phases.
Available formats:
96 Well Plates
Capsules (1.2 mL, 10 mL, 75 mL and 200 mL)
Cassette (0.8 L)
Complementary products:
Rapid A Ligand
Manifold Pilot Holder
Features and Benefits:
Time Savings – faster cycling times with membranes mean less time is required for process development and validation. Moreover, column handling operations are no longer necessary.
Cost reduction – especially for manufacturing of clinical phase material or smaller commercial scale
Risk mitigation – because membranes are less sensitive to air presence or bed instability issues the risk of production stop is less significant
Compact footprint and flexibility- smaller bed volumes can purify the same amounts of target molecules in the same amount of time. Furthermore, there is no need for ancillary equipment related to packing and maintenance.
Scalability
Applications:
Monoclonal antibody (mAb) purification
Fc-region containing fusion proteins
Bi-specifics, multi-specific antibodies

Specifications
Applications:
Application: Capture

Compliance Information:
Biological Reactivity: The final product meets the requirements of the current ISO 10993-5 which is equivalent to the current United States Pharmacopoeia (USP) <87> Biological Reactivity Tests, in vitro.

Connections (Physical):
Connector(s): Female Luer lock

Dimensions:
Bed Height: 4 mm
Dimensions: 37 x 31 mm

Materials of Construction:
Housing Material: Polypropylene (PP)

Operating Conditions:
Maximum Operating Pressure: 0.4 MPa
Maximum Venting Pressure: 0.5 bar, 0.05 MPa, 7 psi
Recommended Flow Rate: 3-5 MV/min (load, elution), 5-10 MV/min ( equilibration, wash)
pH Stability: pH 2 – 14 (short term), pH 3 – 13 (long term)

Physicochemical Information:
Bed Volume: 1.2 mL, 1 mL, 3 mL
Chemical Compatibility: Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
Ligand: Protein A
Reference Protein: Human polyclonal IgG
Typical Dynamic Binding Capacity 10% per mL: ≥ 30 mg/mL
Void Volume: 3.5 mL (4 mm), 4 mL (8 mm)

Product Information:
Brand: Sartobind® Rapid A
Membrane Adsorber Format: Capsules
Membrane Type: Affinity
Pack Size: 5
What you receive: 5 capsules (each Rapid A, S, Q, STIC PA, Phenyl); 1 operating instruction; 1 certificate