Thermo Fisher, 20593, DSG (disuccinimidyl glutarate) Thermo Scientific™

DSG (disuccinimidyl glutarate) Thermo Scientific™ Thermo Scientific Pierce DSG is a water-insoluble, homo-bifunctional N-hydroxysuccinimide ester (NHS-ester) crosslinker often used for conjugating radiolabeled ligands to cell-surface receptors. The NHS ester is the simplest and most commonly used reactive group for crosslinking and labeling proteins and peptides. NHS esters react with primary amines on the N-termini of peptides and the  amine of lysine residues, forming a stable, covalent amide bond and releasing the NHS group.
Thermo Scientific No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.
Features of disuccinimidyl glutarate:
•Reactive groups:NHS ester(both ends)
•Reactive towards:amino groups (primary amines)
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)
• Membrane-permeable, allowing for intracellular crosslinking
• Can increase crosslinking efficiency compared toDSSin some applicationsProduct ReferencesCrosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Form: Powder
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 326.
26
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: NHS Ester
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 7.
7 Å
Water Soluble: No
Chemical Reactivity: Amine-Amine
Cleavable: No
Crosslinker Type: Homobifunctional
Format: Standard, Single-use
Product Type: Crosslinker
Spacer: Short (<10 Å)
Unit Size: Each