Thermo Fisher, A2661501, Dynamis™ Medium

1000 mL Gibco Dynamis liquid medium is specifically designed to offer the highest batch and fed-batch culture performance and yield with recombinant CHO cells in a chemically defined environment. Gibco Dynamis  medium has also been shown to support robust growth of HEK293 cells for adenovirus production. The chemically defined, protein-free, animal origin component-free formulation provides the power to achieve high titers, start process development faster and streamline or simplify transfer to manufacturing scale.
Power to achieve higher titersDynamis Medium is fortified to help maximize recombinant CHO cell growth and protein expression in suspension batch culture, offering 170% greater production than select competitive media with simple glucose supplementation by day 14. Cultures grown in Dynamis Medium extend to even higher titers demonstrating good cell viability out to day 21. This medium can also provide up to 60% greater fed-batch growth and production over glucose-only fed-batch culture for selected cell lines and applications when used withEfficientFeed C+ Supplement.
Power to start process development fasterAs a fortified medium, Dynamis provides the power to get to a high cell density over 10 million cells per mL faster than competitive products and sustains that cell density longer by just maintaining glucose levels. The viable cell growth achieved make it a good choice for scale-up if you have started with CD FortiCHO medium. When paired withEfficientFeed C+ Supplement, it provides a fast and efficient way to develop a process.
When to Use Dynamis Medium
• The cell line you are using is a transfected CHO K1, GS CHO or CHO-S cell line
• The cell line you are using is HEK293 for adenovirus production
• Maximum batch culture cell densities and protein titers are needed
• You have time to adapt cells into a new medium in an effort to maximize titers
• Cell health at harvest is a priority for downstream processingWhen to Consider Another Gibco MediumConsiderCD OptiCHO Mediumwhen:
• You are using a transfected CHO cell line other than CHO K1, GS CHO or CHO-S cell lines
• Optimization of feeding strategies will be part of your base medium selection testing in an effort to maximize productivity
• Your CHO cell line is “finicky,' i.
e. hard to grow or adaptConsiderCD CHO Mediumwhen:
• Your GS CHO cells are recommended to be grown in CD CHO medium
• Your cells have been successfully cultured in CD CHO medium in the past and your process is nearing a regulatory filing (DMF available)ConsiderCD DG44 Mediumwhen:
• You use parental DG44 or DXB11 CHO cells (dhfr-)Design Your Own Media Specific to Your NeedsWhether it’s a bench-level experiment or large scale biomanufacturing process, we offer specialized formats, packaging, and quality levels specific to your needs. WithGibco cGMP Media Custom Servicesyou can put the manufacturing power and years of technical experience of our R&D and Bioproduction Application Specialists to work for you.
ActiCHO is a trademark of Cytiva, BalanCD is a registered trademark of Irvine Scientific Sales Co., Cellvento is a registered trademark of Merck KGAA, EXCELL is a registered trademark of Millipore Sigma, HyCell is a registered trademark of Cytiva, and PowerCHO is a registered trademark of Lonza.
Cell Line: CHO DG44, CHO-S, cGMP Banked, CHO-S, CHO-K1, GS-CHO, HEK293
Format: Bottle(s)
Product Line: Dynamis™
Product Type: AGT Medium
Quantity: 1000 mL
Shelf Life: 18 months
Shipping Condition: Room Temperature
Classification: Animal Origin-free, Chemically-defined, Protein-free, Serum-free
Culture Type: Mammalian Cell Culture
Form: Liquid
Unit Size: Each