Thermo Fisher, A30136, Silencer™ Select Human Cell Cycle Regulation siRNA Library

Silencer™ Select Human Cell Cycle Regulation siRNA Library Proteins that regulate cell division are crucial for controlling cell growth and are therefore potentially important drug targets. TheSilencer™ Select Human Cell Cycle Regulation siRNA Library contains 4417 Ambion™SilencerSelect highly potent and chemically-modified siRNAs targeting 1471 genes. These siRNA gene targets include cyclin-dependent kinases, or CDKs, which are crucial for cell cycle progression, regulators of cell cycle progression such as CIP/KIP family proteins and members of the INK4 family of cell cycle inhibitors, proteins in the retinoblastoma family, and DNA replication factors such as the cell division cycle proteins (CDCs). This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC).
SilencerSelect siRNAs are designed using Thermo Fisher Scientific's leading design algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to ensure the maximum efficacy, specificity and potency required for RNAi screens against cell cycle regulation studies.
Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modificationsHigher efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAsDependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic resultsConvenient—Reduce data de-convolution and accelerate target validation with our arrayed formatCustomizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formatsWhy use theSilencerSelect Human Cell Cycle Regulation siRNA Library?Together with careful bioinformatics selection of gene targets,SilencerSelect siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes. TheSilencerSelect Human Cell Cycle Regulation siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee.
SilencerSelect siRNA libraries empower you with highly potent siRNAs to maximize discovery with even lessAmbionSilencerSelect siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potentSilencerSelect siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. TheSilencerSelect Human Cell Cycle Regulation siRNA Library contains 0.
25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).
Flexibility to meet your workflow needsThermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.
com.
For Use With (Application): RNAi
Product Line: Silencer™Select
Product Type: siRNA Library
Purity: Standard
Quantity: 1 Set
Shipping Condition: Approved for shipment at Room Temperature or on Wet Ice
Format: 96-well Plate
RNAi Type: siRNA
Sample Type: DNA
Species: Human
Unit Size: Each