Abcam, ab103535, Anti-PYCR2 antibody

Size: 100µg
Rabbit Polyclonal PYCR2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PYCR2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PYCR2.Q96C36

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PYCR2 also known as Pyrroline-5-carboxylate reductase 2 is an enzyme involved in proline biosynthesis. It has a molecular mass of approximately 31 kDa. This protein catalyzes the conversion of pyrroline-5-carboxylate to proline an amino acid important for protein synthesis and cellular stress responses. Expressed broadly in human tissues PYCR2 shows notable expression in the liver brain and various muscle tissues indicating its wide functional relevance across different physiological systems.
Biological function summary
The enzyme participates in maintaining proline levels and contributes to cellular osmotic balance and protection against oxidative stress. It is not typically part of a larger protein complex but interacts with other metabolic enzymes that support similar stress response pathways. By catalyzing an important step in the proline biosynthesis pathway PYCR2 helps sustain cellular redox states and protein turnover rates under stressful conditions.
Pathways
PYCR2 plays a significant role in the proline metabolism pathway and glutamate pathway. The functioning of this enzyme in these pathways supports the synthesis and recycling of proline which is important for cell survival under osmotic and oxidative stress conditions. The enzyme cooperates indirectly with proteins such as glutamate dehydrogenase facilitating the metabolic flux through interconnected pathways that manage cellular nitrogen balance.
Mutations in PYCR2 have been associated with conditions such as Hypomyelinating Leukodystrophy 10 and Proline Metabolism Disorder. These conditions often showcase symptoms related to central nervous system abnormalities and metabolic imbalances. The disruptions in PYCR2 activity may also alter interactions with proteins involved in these pathways such as Δ1-Pyrroline-5-carboxylate synthase thereby exacerbating the disease states.