Abcam, ab104430, Anti-NeuroD2 antibody

Size: 100µg
Anti-NeuroD2 antibody (ab104430) is a rabbit polyclonal antibody detecting NeuroD2 in Western Blot, IHC-P, IHC-Fr . Suitable for Human, Mouse . - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-NeuroD2 antibody (ab104430) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse samples.
What is the molecular weight of NeuroD2?
Anti-NeuroD2 (ab104430) specifically detects a band for NeuroD2 (UniProt: Q15784) at a molecular weight of 41kDa.
Trusted by the scientific community
Anti-NeuroD2 (ab104430) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.
Reviewed by scientists
Anti-NeuroD2 (ab104430) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NeuroD2 also known as Neuronal Differentiation 2 is a transcription factor involved in neurogenesis. It weighs approximately 40 kDa. This protein is part of the basic helix-loop-helix (bHLH) family which regulates gene expression. NeuroD2 is expressed mainly in the nervous system particularly in the developing brain and certain adult brain regions. Its expression pattern suggests an important role in neural development and maintenance.
Biological function summary
NeuroD2 influences neuronal differentiation and survival. It guides precursor cells toward a neuronal fate influencing neurogenesis and impacting brain structure. NeuroD2 does not form large protein complexes but interacts closely with other bHLH transcription factors. These interactions help regulate the transcription of genes necessary for the development and maturation of neurons.
Pathways
Transcription factors such as NeuroD2 play key roles in the neurogenesis pathway and the calcium signaling pathway. It operates in tandem with other proteins like NeuroD1 to effectively guide neural precursor cells toward differentiation into mature neurons. Through these pathways NeuroD2 helps regulate genes that are important for brain development and function.
Abnormal NeuroD2 expression relates to neurological conditions like autism spectrum disorders and certain types of epilepsy. Mutations or dysregulation in NeuroD2 can affect associated proteins like REST (RE1-Silencing Transcription factor) which plays a role in neuronal gene silencing. Understanding these connections provides insights into how NeuroD2 influences neural-related diseases and offers potential targets for therapeutic intervention.