Abcam, ab105400, Anti-CXXC4 antibody

Size: 100µg
Rabbit Polyclonal CXXC4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human CXXC4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CXXC4. The exact immunogen used to generate this antibody is proprietary information.Q9H2H0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXXC4 also commonly known as Idax is a protein with a molecular mass of about 30 kDa. The protein features a CXXC motif important in its function. It is normally expressed in tissues such as the brain and heart. In cellular contexts CXXC4 plays roles in epigenetic regulation and is often involved in modulating gene expression. Through its actions CXXC4 influences the cellular environment significantly impacting various processes.
Biological function summary
CXXC4 functions as a negative regulator of the Wnt signaling pathway. It does not form part of a complex but influences Wnt signaling by interacting with Dishevelled proteins. This interaction inhibits the downstream signaling cascade that Wnt usually activates which results in regulated cell growth and differentiation. These actions give CXXC4 significant influence over cellular proliferation and development.
Pathways
The suppression of the Wnt signaling pathway by CXXC4 affects key cellular processes. The Wnt pathway is essential for developmental and regenerative processes and CXXC4's inhibition of this pathway provides a check on excessive cell proliferation. By interacting with Dishevelled proteins CXXC4 prevents unchecked cell growth which keeps a balance in cellular homeostasis. This interaction with Dishevelled highlights the importance of CXXC4 in maintaining cellular regulation within the Wnt signaling context.
CXXC4's role as a Wnt pathway inhibitor links it to various conditions notably colorectal cancer and cardiac disorders. Abnormalities in the Wnt signaling pathway whether due to over-activation or suppression are often implicated in cancer development. CXXC4's interaction with Dishevelled proteins highlights its potential involvement in tumorigenesis. Additionally its role in heart tissue suggests that altered CXXC4 expression or function may contribute to cardiovascular diseases by impacting cardiac growth and repair mechanisms.