Abcam, ab105405, Anti-NLRP7 antibody

Size: 100µg
Rabbit Polyclonal NLRP7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NLRP7. The exact immunogen used to generate this antibody is proprietary information.Q8WX94,
Specificity:At least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NLRP7 also known as NALP7 is a protein involved in immune response signaling. It has a molecular mass of approximately 103 kDa. Scientists have found that NLRP7 is expressed predominantly in reproductive tissues. It belongs to the NOD-like receptor (NLR) family specifically characterized by its role in detecting intracellular pathogens and stress signals. Structurally NLRP7 contains an N-terminal pyrin domain a central nucleotide-binding domain and C-terminal leucine-rich repeats which are essential for its function in pathogen recognition and activation of inflammatory responses.
Biological function summary
This protein plays a significant role in the regulation of inflammation and has been implicated in the formation of inflammasomes. NLRP7 can assemble into multiprotein complexes known as inflammasomes which serve as platforms for the activation of caspase-1 a protease critical for the maturation and secretion of pro-inflammatory cytokines such as IL-1β and IL-18. Additionally researchers recognize the involvement of NLRP7 in reproductive processes where its dysregulation may affect fertility.
Pathways
NLRP7 is notably involved in the inflammatory signaling pathways. It interacts with other inflammasome-related proteins like ASC and caspase-1 to mediate innate immune responses. The assembly and activation of inflammasomes by NLRP7 play a significant role in the immune system's ability to respond to cellular damage and infectious agents. The interaction with ASC leads to the formation of a complex that facilitates the enzymatic cleavage and activation of pro-caspase-1 further propagating the inflammatory cascade.
Scientists have associated NLRP7 predominantly with recurrent hydatidiform moles a gestational trophoblastic disorder. This abnormal growth of trophoblasts the cells that normally develop into the placenta links to mutations in the NLRP7 gene leading to impaired inflammatory signaling. Additionally variations in NLRP7 have connections with immune-related disorders due to its role in regulatory pathways of innate immunity. These disorders often manifest in the reproductive system because of NLRP7’s tissue-specific expression and function.