Abcam, ab106435, Anti-THEM4 antibody

Size: 100µg
Rabbit Polyclonal THEM4 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human, Rat, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human THEM4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human THEM4. The exact immunogen used to generate this antibody is proprietary information.Q5T1C6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THEM4 also known as CTMP (carboxyl-terminal modulator protein) has a mass of approximately 25 kDa. This protein functions by interacting with the protein kinase B (PKB/Akt) signaling pathway modulating its activity. It locates in the cytoplasm and mitochondria and expresses in various tissues with higher levels found in the heart skeletal muscle and liver. THEM4 plays a role in regulating cellular processes related to metabolism and apoptosis.
Biological function summary
THEM4 affects several cellular mechanisms. It associates with mitochondrial homeostasis and energy metabolism. THEM4 acts as an inhibitory regulator of Akt which is critical for cell survival and growth processes. It interacts with other proteins to influence energy homeostasis contributing to lipid metabolism regulation. As part of protein complexes THEM4 may function in concert with other regulatory proteins to perform its roles efficiently.
Pathways
THEM4 significantly impacts the PI3K/Akt signaling pathway facilitating communication between the cell membrane and intracellular targets affecting cell growth and survival. It also links to the mTOR pathway which THEM4 influences through its interaction with Akt. THEM4 modulates these critical pathways by interacting with proteins such as PTEN which serves as a phosphatase and GSK-3β a kinase involved in cellular glycogen metabolism.
THEM4 connects to cancer and cardiovascular diseases through its regulatory effects on Akt activity. In cancer altered THEM4 function can lead to excessive cell survival and growth contributing to tumorigenesis. Its modulation of Akt implicates THEM4 in cardiovascular disease where Akt is critical for maintaining cardiac function. THEM4's interaction with proteins like Bcl-2 in apoptosis and p53 in DNA repair and cell cycle control further connects it to these disorders offering avenues for targeted therapies.