Abcam, ab106471, Anti-GALNT10 antibody

Size: 100µg
Rabbit Polyclonal GALNT10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Polypeptide N-acetylgalactosaminyltransferase 10.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Polypeptide N-acetylgalactosaminyltransferase 10. The exact immunogen used to generate this antibody is proprietary information.Q86SR1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GALNT10 also known as polypeptide N-acetylgalactosaminyltransferase 10 is a member of the GalNAc-T family of enzymes. The enzyme plays an important mechanical role by catalyzing the transfer of N-acetylgalactosamine (GalNAc) to serine and threonine residues on proteins a process called O-glycosylation. This enzymatic activity is critical for proper protein modification and function. GALNT10 has a molecular mass of approximately 68 kDa. It is expressed in a variety of tissues notably in the liver which indicates its extensive role in protein processing within this organ.
Biological function summary
Polypeptide N-acetylgalactosaminyltransferase 10 influences the initial steps of mucin-type O-glycosylation which significantly affects protein stability and cell signaling. It is not part of a large enzyme complex but its function is integral to the regulation of substrate-specific modifications. This protein aids in the modulation of various glycoproteins impacting diverse physiological processes. Alterations in its activity potentially lead to changes in cell-cell interactions and mucosal protection.
Pathways
GALNT10 is involved in O-glycan biosynthetic pathways where its role is pivotal in glycan structure formation and diversity. This pathway enables the proper glycosylation of proteins that are essential for cell-cell communication and adhesion. GALNT10's activity relates closely to other glycosyltransferases within this pathway including GALNT1 reflecting its cooperative nature within glycosylation networks. Moreover it supports the broader glycosylation landscape by influencing the availability of glycosylation sites on various protein substrates.
GALNT10 has associations with specific conditions such as cancers and metabolic syndromes. Abnormal function or expression of this enzyme can contribute to tumorigenesis due to its influence on glycosylation patterns that affect cell adhesion and signaling. The enzyme is also linked to liver disorders arising from its high expression in liver tissue and its impact on protein processing. In the context of cancer GALNT10’s interactions with similar glycosylation enzymes like GALNT3 illustrate its role in modifying glycan structures which are critical for cellular transformation and cancer progression.