Abcam, ab106827, Anti-PITX3/PTX3 antibody

Size: 100µg
Goat Polyclonal PITX3/PTX3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PITX3 aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PITX3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O75364,
Specificity:ab106827 is not expected to cross-react with PITX1 and PITX2.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab106827 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PITX3 also known as paired-like homeodomain transcription factor 3 is a transcription factor that plays a role in gene expression regulation. It has a mass of approximately 32 kDa. PITX3 is predominantly found in the eye lens and dopaminergic neurons specifically in the substantia nigra. This region of the brain is vital for motor control. PITX3 expression is important in ocular development and maintaining cellular function in these regions.
Biological function summary
The PITX3 protein regulates critical processes in ocular development and survival of dopaminergic neurons. It is not part of a complex itself but works closely with other regulatory factors influencing various genes involved in neuron differentiation and eye structures. PITX3's activity in these biological systems is fundamental to proper development and cellular homeostasis.
Pathways
PITX3 plays a significant role in the development and function of dopaminergic neurons of the substantia nigra as well as in the formation of eye tissues. It is involved in pathways like Wnt and dopamine synthesis which are critical for neuronal function and vision development. PITX3 interacts with proteins such as Nurr1 in these pathways contributing to neuron survival and differentiation. The balance of these processes directly impacts the development and function of target tissues.
PITX3 mutations are closely associated with ocular diseases like congenital cataracts and neurodegenerative disorders such as Parkinson's disease. In the context of Parkinson's disease PITX3's role alongside proteins like alpha-synuclein is critical; dysregulation in their interaction can lead to dopaminergic neuron degeneration. Understanding PITX3 interactions with other proteins helps illuminate the molecular basis of these conditions offering potential therapeutic targets.