Abcam, ab108368, Anti-CD97 antibody [EPR4427]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CD97 antibody. Suitable for IHC-P, IP, Flow Cyt, WB, ICC/IF and reacts with Human samples. Cited in 13 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4427,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IP, ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.35% Sodium citrate, 0.17% Sodium chloride, 0.05% BSA, 0.03% EDTA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD97 also known as adhesion G protein-coupled receptor E5 is a member of the EGF-TM7 subfamily of adhesion GPCRs. The protein has a mass of approximately 83-93 kDa and consists of distinct extracellular transmembrane and cytoplasmic domains. CD97 expresses highly on cells of the immune system especially granulocytes activated T-lymphocytes and smooth muscle cells. Researchers frequently link CD97 expression to immune cell activation and migration processes.
Biological function summary
CD97 plays a significant role in cell communication and adhesion. The protein is part of a multiprotein complex and interacts with chondroitin sulfate and other heparan sulfate proteoglycans. This interaction modulates inflammatory responses and tissue remodeling. CD97 influences immune responses by mediating cellular interaction and signaling through its long extracellular domain. Its activity is essential for leukocyte trafficking and extravasation.
Pathways
CD97 participates in important cell adhesion and immune system pathways. It interacts notably with the EGF-like crossover domains and the GPCR pathways. Related proteins such as CD55 also known as decay-accelerating factor interact with CD97 influencing the immune regulatory processes. These interactions enhance our understanding of leukocyte recruitment and the maintenance of tissue architecture during inflammatory responses.
CD97 is associated with autoimmune diseases and cancer. High CD97 expression levels relate to diseases like rheumatoid arthritis and certain types of tumors including gastric carcinoma. In cancer CD97 interacts with integrin molecules promoting metastasis and tumor invasion. Understanding CD97's connection to integrins and other components could provide insights into therapeutic targets for autoimmune and cancer treatment.