Abcam, ab109591, Anti-DDX55 antibody

Size: 100µg
Rabbit Polyclonal DDX55 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDX55 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DDX55 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q8NHQ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX55 also known as DEAD box protein 55 is a member of the DEAD box protein family. Mechanically it acts as an RNA helicase involved in altering RNA secondary structure. This function plays a role in RNA processing events including transcription splicing and ribosome assembly. DDX55 has a mass of approximately 67 kDa and expresses in various tissues indicating its broad functional importance in cellular biology.
Biological function summary
Many RNA processing activities depend on RNA helicases like DDX55. It influences the regulation of gene expression by participating in RNP complex remodeling. It interacts dynamically with other molecules during RNA metabolic processes although not strictly part of a single complex. Its activity affects cellular growth and maintenance showing its involvement in essential biological processes.
Pathways
DDX55 engages in important cellular processes such as RNA splicing and translation initiation. It associates with pathways regulating gene expression at the post-transcriptional level. DDX55 shows an interaction with proteins like eIF4A a vital component of the translation initiation complex influencing the initiation steps of protein synthesis. This relationship underlines its involvement in mRNA lifecycle management.
Errors in DDX55 function or expression can relate to conditions like cancer and neurodegenerative diseases. Its role in gene expression links it to the abnormal cellular proliferation seen in some cancers. Additionally DDX55 interacts with proteins like p53 an important regulator of the cell cycle and apoptosis. Disruptions in these interactions may contribute to the development of disease by affecting cell survival pathways.