Abcam, ab109750, Anti-Kir2.1/KCNJ2 antibody [EPR4530]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Kir2.1/KCNJ2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 12 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4530,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Kir2.1 protein also known as KCNJ2 belongs to a family of inward-rectifier potassium channels. Kir2.1 is important for setting and stabilizing the resting membrane potential. It has a molecular mass of approximately 48 kDa. Kir2.1 is mainly expressed in the heart and brain tissues and it facilitates the flow of potassium ions across the cell membrane with high efficiency. This modulation of potassium ion movement is critical for maintaining membrane potential and is vital for the normal electrical activity in excitable tissues.
Biological function summary
This process aids in the regulation of cellular excitability. Kir2.1 is an integral part of cell membranes and often associates with other proteins to form a functional channel complex. This complex plays a role in neuronal signaling and cardiac rhythm regulation contributing to various physiological functions in muscle and nerve tissue. Its roles underpin how potassium currents modulate nerve impulses and heartbeats reflecting its participation in the body's complex communication and control systems.
Pathways
The Kir2.1 channel influences the cardiac action potential and is involved in maintaining the stability of the heart’s electrical signaling. It is part of the cardiac conduction pathway. The channel interacts with other cardiac proteins like KCNJ3 and KCNJ5 complementing their function in the repolarization phase of the cardiac action potential. Kir2.1's presence in pathways responsible for repolarization highlights the precision needed for effective cardiac and neurological functions.
Mutations in the Kir2.1 gene KCNJ2 relate to Andersen-Tawil syndrome and cardiac arrhythmias. Andersen-Tawil syndrome characterized by periodic paralysis cardiac arrhythmias and developmental anomalies highlights the multifaceted role Kir2.1 plays in cellular function. Kir2.1 mutations disrupt electrical stability in heart and skeletal muscle tissues. Similar mutations associate with connections to other membrane proteins like KCNH2 often exacerbating arrhythmic risk a critical factor in heart-related conditions.