Abcam, ab113496, Anti-ALDH1L2 antibody

Size: 100µg
Rabbit Polyclonal ALDH1L2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Mitochondrial 10-formyltetrahydrofolate dehydrogenase aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Mitochondrial 10-formyltetrahydrofolate dehydrogenase aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q3SY69

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH1L2 also known as 10-formyltetrahydrofolate dehydrogenase 2 plays an important role in folate metabolism. It is a mitochondrial enzyme with an approximate mass of 100 kDa. This protein catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide impacting cellular methylation reactions. ALDH1L2 expresses mainly in the liver and kidney although its presence spans various tissues contributing to its diverse functionalities.
Biological function summary
ALDH1L2 facilitates important metabolic processes related to one-carbon metabolism a fundamental pathway in cell growth and replication. This protein functions as part of the formyltransferase complex collaborating with other enzymes to regulate folate and methionine cycles. This involvement in these cycles reflects its role in purine and nucleotide biosynthesis influencing genetic material synthesis and cellular repair mechanisms.
Pathways
The enzymatic activity of ALDH1L2 intersects the folate-mediated one-carbon metabolism and methionine cycle. This protein connects with the methionine synthase and methylenetetrahydrofolate reductase both vital in homocysteine metabolism. Its action ensures adequate supply of substrates required for DNA synthesis and repair suggesting its importance in maintaining genomic stability and nucleotide balance.
ALDH1L2 exhibits potential links to cancer and neurodegenerative conditions. Dysregulation of this enzyme could lead to folate imbalance influencing tumorigenesis by altering DNA methylation patterns. In neurodegenerative diseases variations in one-carbon metabolism levels have connections with Alzheimer's disease. Interaction with proteins like methionine synthase suggests that changes in this pathway could exacerbate neurological decline highlighting ALDH1L2 as a potential therapeutic target.