Abcam, ab116819, Recombinant Human OP-2 protein

Size: 10µg
Recombinant Human OP-2 protein is a Human Fragment protein, in the 274 to 362 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P34820,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Product details:
This product was previously labelled as BMP8b.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OP-2 also known as "Op protein" or "Anti-Op" is a well-characterized protein with a mass of approximately 45 kDa. This protein is widely expressed in various tissues including the brain liver and spleen. OP-2 has a significant role in several physiological processes through its mechanical functions. As a molecular component it engages in protein interactions that influence cellular communication and signal transduction. Researchers have devoted considerable attention to understanding the complete range of its interactions.
Biological function summary
The protein participates in essential regulatory networks and modulates cellular responses to external stimuli. It often acts as a part of multi-protein complexes that are critical for its function. These complexes facilitate the protein's ability to engage in cell cycle regulation and apoptosis. Additionally OP-2 influences the stability and degradation of certain denatured proteins which emphasizes its role in maintaining cellular homeostasis. The protein's significance extends to acting as a mediator in immune responses.
Pathways
OP-2 plays important roles in both the MAPK/ERK and NF-kB signaling pathways. These pathways are integral to the regulation of cell proliferation differentiation and survival. In the MAPK/ERK pathway OP-2 interacts with a variety of kinases and phosphatases impacting their activity and consequently affecting transcription factors such as c-Myc and Fos. Meanwhile within the NF-kB pathway OP-2 can modulate the activity of IKK-γ which is an important regulatory protein controlling NF-kB activation. Through these interactions OP-2 influences cellular responses to stress and inflammation.
OP-2 shows a strong connection to certain cancers and autoimmune diseases. For instance aberrations in OP-2 function or expression levels have been associated with breast cancer where it affects tumor growth and metastasis. Researchers have also found links between OP-2 and multiple sclerosis a chronic autoimmune condition suggesting its involvement in immune regulation. Other proteins such as TNF-α often intersect with OP-2 in these diseases contributing to disease pathology. Understanding these associations helps in identifying potential therapeutic targets for intervention.