Abcam, ab117412, Anti-CCK4 antibody

Size: 50µg
Rabbit Polyclonal CCK4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human PTK7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human PTK7.Q13308

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The anti-serum was pre-cleared for tag protein and then affinity purified on immobilized PTK7 affinity chromatography., Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCK4 also known as PTK7 protein is a receptor tyrosine kinase. The molecular mass of the CCK4 protein is approximately 118 kDa. It is expressed in various tissues including the placenta lung kidney and colon. The presence of CCK4 is particularly noted in developmental tissues and has roles in embryogenesis. Despite its classification as a receptor tyrosine kinase CCK4 lacks catalytic activity indicating its unique functional properties.
Biological function summary
CCK4 participates in cellular signaling involved in adhesion and cell migration. It localizes predominantly in the membranes participating in complex cellular environments such as the Wnt signaling complex. This suggests a role in maintaining cellular architecture and signaling pathways that influence developmental processes. Its interactions within these complexes can help maintain balance and functional integrity in developing tissues.
Pathways
CCK4 engages in vital pathways influencing cell adhesion and movement including the planar cell polarity (PCP) pathway and Wnt signaling pathway. Within these pathways CCK4 interacts with proteins such as Dishevelled and Frizzled establishing its role in guiding cellular and developmental patterns. These interactions regulate important aspects of cell polarity and directional movement during embryonic development.
CCK4 has been implicated in cancer and congenital malformations. In cancers such as colorectal carcinoma altered CCK4 expression correlates with cancer progression possibly through interaction with associated proteins like ROR2. Similarly its function in neural tube development suggests a role in congenital disorders affecting the spine and nervous system. This connection highlights the importance of CCK4 in both cancer biology and developmental disorders.