Abcam, ab117826, Anti-NEDD4 antibody

Size: 100µg
Rabbit Polyclonal NEDD4 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NEDD4 aa 700-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NEDD4 aa 700-800. The exact immunogen used to generate this antibody is proprietary information.P46934

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NEDD4 protein also called NEDD4-1 is an E3 ubiquitin-protein ligase. It has a role in tagging proteins with ubiquitin molecules marking them for degradation by the proteasome. This protein has a molecular mass of approximately 120 kDa. High expression of NEDD4 occurs in tissues like the brain heart and skeletal muscle. The activity of NEDD4 impacts various processes ensuring protein quality control and regulation within cells.
Biological function summary
The impact of NEDD4 protein extends beyond its basic mechanical function. It plays an important role in cell signaling development and even adjusting cell volume. NEDD4 participates in forming a ubiquitin-protein ligase complex engaging with multiple substrates to transfer ubiquitin. It modulates key signaling pathways influencing cellular responses and maintaining healthy cell functioning.
Pathways
NEDD4 activity is embedded in key cellular processes. It is especially integral in the PI3K/AKT signaling and Wnt signaling pathways where it can influence signal transduction and cellular growth. NEDD4 ubiquitin ligase family members like NEDD4-2 are often seen working alongside it. These pathways involve other proteins such as PTEN which NEDD4 regulates affecting cell proliferation and survival.
NEDD4 holds significant connections to cancer and neurodegenerative diseases. Elevated levels of NEDD4 can contribute to oncogenesis particularly in cancers where dysregulation in protein degradation occurs. The aberrant activity of NEDD4 links to neurodegenerative diseases as it affects the turnover of neuronal proteins. It shares a complex relationship with PTEN in diseases considering their interaction can alter cellular pathways often distorted in pathological conditions.