Abcam, ab119338, Anti-PRC1 antibody [16F2]

Size: 100µg
Mouse Monoclonal PRC1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Protein regulator of cytokinesis 1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:16F2,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Protein regulator of cytokinesis 1.O43663

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRC1 also known as Protein Regulator of Cytokinesis 1 affiliates with cellular division mechanics. This protein weighs approximately 72 kDa. PRC1 localizes in the nucleus during the interphase and redistributes to the spindle midzone during mitosis. It plays a role in the stabilization of microtubules facilitating proper cytokinesis. Expression of PRC1 occurs in several human tissues notably in dividing cells.
Biological function summary
PRC1 functions in accurately regulating actin and microtubule interaction during cell division. As a part of the centralspindlin complex it ensures correct spindle midzone formation and serves as a marker for the cleavage furrow. Cellular events coordinated by PRC1 involve chromosomal segregation and rapidly proliferating cells express it to maintain integrity during mitotic processes.
Pathways
PRC1 contributes significantly to the mitotic spindle checkpoint. It participates in the Aurora B kinase pathway interacting with proteins like KIF4A and PLK1. This protein ensures the transition from metaphase to anaphase is precise preventing aneuploidy. As a pathway node PRC1 manages signal transduction facilitating cell cycle regulation and fidelity.
Dysregulation of PRC1 expression associates with cancer notably prostate and breast cancer. Tumor cells often display altered PRC1 activity linked to abnormal cell proliferation. The protein interacts with the oncogenic proteins such as p53 indicating a role in tumorigenesis and progression. Exploring therapeutic strategies targeting PRC1 could provide insights into cancer treatment.