Abcam, ab120121, D-Cycloserine, NMDA glycine site agonist

Size: 1g / 5g
MW 102.09 Da, Purity >99%. Partial agonist at the NMDA receptor glycine recognition site. Enhances learning and memory in vivo . Perfomance enhancer in a variety of cognitive models. Also available in simple stock solutions (ab146677) - add 1 ml of water to get an exact, ready-to-use concentration.
Key facts
CAS number:68-41-7,
Purity:>99%,
Molecular weight:102.09 Da,
Molecular formula:C3H6N2O2,
PubChem:6234,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Cycloserine,
Biological description:Partial agonist at the NMDA receptor glycine recognition site. Enhances learning and memory in vivo. Perfomance enhancer in a variety of cognitive models.Also available in simple stock solutions (ab146677) - add 1 ml of water to get an exact, ready-to-use concentration.,
Canonical smiles:C1C(C(=O)NO1)N,
Isomeric smiles:C1[C@H](C(=O)NO1)N,
InChi:InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1,
InChiKey:DYDCUQKUCUHJBH-UWTATZPHSA-N,
IUPAC Name:(4R)-4-amino-1,2-oxazolidin-3-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glutamate Receptor 1 (AMPA subtype) also known as GRIA1 is a type of ionotropic glutamate receptor that mediates fast synaptic transmission in the central nervous system. The protein has a molecular weight of approximately 107 kDa. You find it is mainly expressed in the postsynaptic membranes of neurons. The structure of GRIA1 includes several key domains essential for its function including ligand-binding domains that interact with glutamate triggering conformational changes that open ion channels.
Biological function summary
Glutamate receptors like the GRIA1 play an important role in synaptic plasticity and memory formation through involvement in excitatory neurotransmission. This receptor functions as part of a tetrameric complex where it interacts with other AMPA receptor subunits. Through its ion channel GRIA1 allows the flow of sodium and potassium ions which are essential for depolarizing the postsynaptic neuron and transmitting the nerve signal.
Pathways
The GRIA1 receptor is a significant component of the glutamatergic synapse pathway. This pathway is essential for learning and memory mechanisms in the brain and involves NMDA and AMPA receptors. GRIA1 interacts with proteins such as D-cycloserine an NMDA agonist affecting synaptic responses and plasticity. Its function in this pathway connects it to long-term potentiation a cellular process underlying memory and learning.
Alterations or mutations in GRIA1 can contribute to neurodevelopmental disorders such as schizophrenia and epilepsy. The receptor's interaction with other proteins such as HIF-1 alpha may influence cellular responses to hypoxia affecting those diseases' pathophysiology. Modulation of GRIA1 activity shows potential therapeutic strategies possibly involving agents like D-cycloserine which can impact related pathways and offer benefits in treating cognitive deficits.