Abcam, ab213679, Anti-Jarid2 antibody

Size: 100µL
Rabbit Polyclonal Jarid2 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human JARID2 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human JARID2 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q92833

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Jarid2 also known as Jumonji or Jumonji AT-rich interactive domain 2 serves important functions in chromatin dynamics. It is a protein with a mass of approximately 125 kDa and plays a role as a regulatory factor in gene expression. Jarid2 expresses across several tissues particularly in those undergoing developmental processes such as the heart and central nervous system. The protein helps to recruit other proteins to chromatin impacting the regulation of gene activity.
Biological function summary
Jarid2 interacts with the polycomb repressive complex 2 (PRC2) which modulates chromatin structure to suppress gene transcription. This interaction is key for the protein's role in epigenetic regulation. As a component of PRC2 Jarid2 influences the methylation of histone H3 at lysine 27 (H3K27) a modification critical for controlling developmental genes' expression. Its function ensures proper regulation of gene programs that affect cell fate decisions during embryogenesis.
Pathways
Jarid2 integrates into the gene silencing pathways involving PRC2 influencing pathways like the Wnt/β-catenin signaling pathway. This influence occurs by modulating target genes that PRC2 controls such as those involved in cellular differentiation. Additionally it relates to proteins such as Ezh2 another PRC2 member. Together these components maintain repression of genes impacting cell proliferation and differentiation.
Jarid2 proves significant in conditions like cardiac hypertrophy and certain cancers. Its deregulation may lead to altered expression of genes necessary for cardiac muscle cell size and function contributing to hypertrophy. In cancer changes in Jarid2 expression or function can disrupt normal growth control as seen in interactions with proteins like Suz12 another PRC2 associate. Understanding these connections helps to outline potential therapeutic targets for intervention.