Abcam, ab215116, Kifunensine, class I alpha-mannosidase inhibitor

Size: 1mg / 5mg
MW 232.19 Da. Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC 50 = 20-50 nM for mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense . Used to suppress Endoplasmic Reticulum-Associated Degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity.
Key facts
CAS number:109944-15-2,
Form:SolidSee storage information,
Molecular weight:232.19 Da,
Molecular formula:C8H12N2O6,
PubChem:130611,
Nature:Synthetic,
Solubility:Soluble in DMSO up to 35 mg/ml,
Biochemical name:Kifunensine,
Biological description:Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC50 = 20-50 nM for mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense. Used to suppress Endoplasmic Reticulum-Associated Degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity.,
Canonical smiles:C(C1C(C(C(C2N1C(=O)C(=O)N2)O)O)O)O,
Isomeric smiles:C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H]2N1C(=O)C(=O)N2)O)O)O)O,
InChi:InChI=1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1,
InChiKey:OIURYJWYVIAOCW-PQMKYFCFSA-N,
IUPAC Name:(5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-2,3-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions