Abcam, ab218037, Anti-HES6 antibody

Size: 100µL
Rabbit Polyclonal HES6 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HES6 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HES6 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q96HZ4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HES6 also known as Hairy and Enhancer of Split-6 is a protein involved in transcriptional regulation. It has a molecular mass of approximately 25 kilodaltons. Researchers find HES6 expression in multiple tissues including the brain muscle and pancreas. As a member of the bHLH (basic helix-loop-helix) transcription factor family HES6 negatively regulates transcription typically by antagonizing the activity of other transcription factors.
Biological function summary
HES6 influences cell differentiation and the timing of neurogenesis. It does not commonly act as part of a large complex but rather modulates activity by interacting directly with other transcription factors and regulatory proteins. Through these interactions HES6 helps control gene expression patterns important for the development of neural and muscular structures.
Pathways
HES6 participates in the Notch signaling pathway a critical mechanism for cell fate decisions. HES6 interacts with proteins such as HES1 and inhibition of some Notch pathway activities. This interaction influences cell differentiation processes particularly in the nervous system. Another pathway involving HES6 is the Wnt signaling pathway where it acts as a modulator in different cellular contexts though precise mechanical interactions within this pathway continue to be under investigation.
Researchers have associated HES6 with neurodegenerative diseases and muscle development disorders. In Alzheimer's disease for example dysregulation of the Notch pathway involving proteins such as HES1 and HES6 may contribute to pathogenesis. In muscular dystrophy alterations in the expression of HES6 could impact muscle repair and regeneration processes making it a target of interest for understanding and potentially treating such conditions.