Abcam, ab220088, Anti-AP-B antibody

Size: 100µL
Rabbit Polyclonal AP-B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RNPEP aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RNPEP aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q9H4A4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target AP-B also known as Alkaline Phosphatase B plays a critical role in dephosphorylation processes. This protein weighs approximately 68 kDa. Researchers find AP-B expressed in various tissues including liver bone kidneys and the placenta. The enzyme functions optimally in an alkaline environment and serves different roles depending on its location. AP-B's activity in these tissues highlights its diverse functional capacity from bone mineralization to liver metabolism.
Biological function summary
The role of this enzyme impacts the regulation of phosphate groups on peptides and other molecules. AP-B often forms part of larger enzymatic complexes contributing to the deactivation of molecules by removing phosphate groups. This action influences cell growth differentiation and signal transduction. Additionally due to its expression in the intestines AP-B also plays a role in digestion aiding in nutrient absorption by catalyzing the breakdown of nucleotides.
Pathways
Several lines of evidence show that AP-B integrates into the bone Gla protein pathway and the hepatic detoxification pathway. In bone Gla protein synthesis AP-B interacts with osteocalcin key for bone mineralization and calcium binding. Within the detoxification pathway in hepatic systems AP-B aids in processing various xenobiotics and endogenous substrates. Coordination with these proteins underlines AP-B's role in maintaining homeostasis and its enzymatic importance in metabolic pathways.
AP-B levels correlate with conditions such as Paget's disease of bone and hyperparathyroidism. For instance elevated AP-B activity is often a marker for increased osteoblastic activity in Paget's disease where malfunction leads to excessive bone resorption and formation. Moreover hyperparathyroidism can result in augmented activity of AP-B linked to disturbances in calcium and phosphate balance. In these conditions AP-B interacts with proteins such as parathyroid hormone which influence bone remodeling and calcium homeostasis.