Abcam, ab221058, Anti-GRHL3 antibody

Size: 100µL
Rabbit Polyclonal GRHL3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRHL3 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRHL3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q8TE85

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRHL3 also known as Grainyhead-like 3 functions mainly as a transcription factor. This protein weighs approximately 68 kDa and manages gene expression by binding to specific DNA sequences. GRHL3 is essential for keratinocyte differentiation and maintains epidermal integrity. The gene encoding GRHL3 shows expression mainly in epithelial tissues such as skin lungs and bladder.
Biological function summary
Grainyhead-like 3 coordinates the development and maintenance of epithelial tissues. It plays a significant role in wound healing by promoting cell migration and adhesion. GRHL3 forms part of a regulatory complex interacting with other transcription factors to control target genes involved in skin barrier formation. Besides its regulation extends to processes like epithelial-mesenchymal transition.
Pathways
The involvement of GRHL3 is important in the epidermal growth factor receptor (EGFR) signaling pathway and the Wnt signaling pathway. These pathways allow GRHL3 to influence cell proliferation and differentiation. The protein interacts with others like EGFR and beta-catenin in these contexts which shows its importance in skin physiology and development.
GRHL3 is associated with skin-related conditions including psoriasis and non-melanoma skin cancer. Mutations or dysregulation in GRHL3 expression link to aberrant skin cell proliferation and differentiation. In these contexts GRHL3 connections to proteins such as p53 and NF-kB have been identified indicating potential pathways for therapeutic targeting and intervention strategies.