Abcam, ab221645, Anti-PSMD11 antibody

Size: 100µL
Rabbit Polyclonal PSMD11 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSMD11 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PSMD11 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O00231

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMD11 also known as RPN-6 is a regulatory subunit of the proteasome 26S. It is approximately 50 kDa in mass and plays an essential role in the proteasome's function responsible for protein degradation within cells. PSMD11 is broadly expressed in various tissues including high expression in the brain heart and skeletal muscle. Its mechanical role involves binding to other subunits to stabilize the proteasome structure and facilitate substrate entry into the proteolytic core.
Biological function summary
PSMD11 is essential for the proper assembly and activity of the 26S proteasome complex which is important for ubiquitin-mediated proteolysis. This process controls protein turnover and regulates the concentration of various proteins to maintain cellular homeostasis. PSMD11 enhances the degradation of misfolded or damaged proteins therefore preventing the accumulation of toxic protein aggregates within cells. Its expression levels can modulate the proteasome activity in response to cellular conditions.
Pathways
PSMD11 plays a significant role in the ubiquitin-proteasome pathway which is critical for protein homeostasis and degradation of regulatory proteins. This pathway involves several important proteins including ubiquitin which tags substrates for degradation. PSMD11 also interfaces with signaling pathways that regulate cell cycle progression and apoptosis such as interactions with p53 and c-Myc proteins. These pathways ensure the balance between cell survival and programmed cell death.
PSMD11 links directly to conditions involving proteasome dysfunction such as neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. Dysregulation of PSMD11 can impact proteasome activity leading to the buildup of unwanted proteins that contribute to these conditions. Additionally PSMD11's interaction with proteins like alpha-synuclein and tau in these diseases highlights its relevance in understanding their pathogenesis.