Abcam, ab221904, Anti-RPS27/MPS1 + RPS27L antibody

Size: 100µL
Rabbit Polyclonal RPS27L antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPS27 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RPS27 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P42677

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS27 also known as MPS1 or RPS27L is a ribosomal protein with a molecular weight of approximately 9.6 kDa. This protein is expressed in a wide range of tissues and contributes to the structural and functional integrity of the 40S ribosomal subunit. RPS27 is an integral component of ribosome biogenesis playing a role in the assembly of ribosomal proteins and rRNA necessary for protein synthesis.
Biological function summary
RPS27 performs functions beyond its structural component of the ribosome. It engages in the regulation of cell proliferation and apoptosis acting as part of the molecular machinery that ensures cell cycle progression and programmed cell death. RPS27 interacts with other ribosomal proteins and non-ribosomal factors suggesting its involvement in a larger protein complex that maintains cellular homeostasis. This protein can influence p53-mediated responses highlighting its roles in important cellular processes.
Pathways
RPS27 integrates into the p53 signaling pathway and the mTOR signaling pathway. These pathways regulate vital functions such as cell growth cell cycle and response to DNA damage. RPS27 aligns its activities with proteins like MDM2 and S6K1 which are critical in managing cell survival and metabolic regulation. Its interaction in these pathways positions RPS27 as a regulatory node in controlling cell fate decisions and response to cellular stressors.
RPS27 shows relevance in cancer and anemias. Altered expression or mutations in this protein have associations with tumorigenesis connecting it with cancer-related proteins such as p53 and MDM2. Its involvement in the regulation of erythropoiesis links it to anemias especially those arising from ribosome biogenesis defects. These associations establish RPS27 as a significant target for understanding and potentially addressing these medical conditions.