Abcam, ab222385, Anti-ARMC2 antibody

Size: 100µL
Rabbit Polyclonal ARMC2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARMC2 aa 650-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARMC2 aa 650-750. The exact immunogen used to generate this antibody is proprietary information.Q8NEN0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARMC2 or Armadillo Repeat Containing 2 operates as a protein involved in various cellular processes. This protein weighs approximately 88 kDa and has been identified in several tissues with a strong presence in the testis. It contains armadillo repeats which help develop protein-protein interactions making it influential in cellular signalling.
Biological function summary
ARMC2 participates in the assembly of protein complexes. Its primary role involves maintaining cellular structural integrity and mediating signal transduction. Through its armadillo repeats ARMC2 binds with other proteins to create multiprotein complexes that hold importance in cellular functions. By interacting with these proteins it ensures that intracellular processes such as transport and communication function correctly.
Pathways
ARMC2 acts in conjunction with key cellular pathways like the Wnt signalling pathway. This pathway involves several proteins that contribute to embryonic development and cell differentiation. ARMC2 shows strong interactions with pathways that include proteins such as beta-catenin an essential player in the Wnt pathway. These partnerships help ARMC2 influence gene transcription and cellular behavior.
ARMC2's interactions hint at a possible link to infertility. Its malfunction or abnormal expression may disrupt testicular function impacting spermatogenesis. In some cases correlations exist between ARMC2 and proteins like ZMYND15 which share roles in maintaining testicular health. Moreover variations in ARMC2 might contribute to reproductive-related disorders suggesting its importance in clinical settings.