Abcam, ab222806, Anti-Neurexin I beta antibody

Size: 50µg / 50µL
Rabbit Polyclonal NRX1B antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NRXN1 aa 1200-1400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NRXN1 aa 1200-1400. The exact immunogen used to generate this antibody is proprietary information.Q9ULB1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurexin I beta also known as Neurexin-1 is a synaptic cell adhesion molecule that plays a significant role in the nervous system. This protein is part of the neurexin family and spans the cell membrane linking neurons together. It typically weighs around 61 kDa. Neurexin I beta is expressed widely in the brain particularly in the synaptic regions. It facilitates the communication between presynaptic and postsynaptic neurons important for neurotransmitter release.
Biological function summary
Neurexin I beta participates in synaptic vesicle fusion and supports synapse formation. It forms part of a complex interacting system with neuroligins and LRRTMs maintaining synaptic stability and organization. Neurexin I beta's role in synapse assembly and function suggests its importance in neurodevelopmental processes. Its interaction with neuroligins indicates its involvement in synaptic specification.
Pathways
Neurexin I beta is engaged in synaptic adhesion and neurotransmitter release pathways. It associates with neuroligins and synaptotagmin maintaining synaptic structure and function. The neurotransmitter release pathway includes calcium ion entry triggering synaptic vesicle fusion. The interactions between Neurexin I beta and these proteins ensure efficient synaptic signaling and plasticity essential for cognitive functions.
Altered Neurexin I beta function has been linked to neurodevelopmental disorders particularly autism spectrum disorders and schizophrenia. Its association with neuroligins plays a role in these conditions due to the disrupted synaptic connectivity and communication. In autism spectrum disorders mutations in Neurexin I beta and neuroligins have been observed suggesting their involvement in synaptic dysfunctions. In schizophrenia synaptic plasticity disruptions connect Neurexin I beta's altered pathways to the disease pathogenesis.