Abcam, ab222844, Anti-LTBP4 antibody

Size: 50µL
Rabbit Polyclonal LTBP4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LTBP4 aa 950-1200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LTBP4 aa 950-1200. The exact immunogen used to generate this antibody is proprietary information.Q8N2S1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein LTBP4 also known as Latent Transforming Growth Factor Beta Binding Protein 4 plays an important mechanical role in the extracellular matrix. It is involved in the storage and activation of TGF-beta. Weighing approximately 210 kDa this protein is mainly expressed in connective tissues including skin lung and kidney tissues. It helps ensure proper assembly of elastic fibers and is important in maintaining the structural integrity of the extracellular matrix.
Biological function summary
LTBP4 associates with proteins to form larger complexes and regulates the availability of TGF-beta within the cell environment. Its function relates closely to modulating growth factors that control cell proliferation differentiation and migration. LTBP4's role in elastic fiber structure links it to essential biological processes such as tissue repair and fibrosis. Its presence within the extracellular matrix implies strong interactions with other structural proteins that lead to the proper function of connective tissue.
Pathways
LTBP4 directly influences the TGF-beta signaling pathway important for developmental processes and homeostasis in tissues. The protein plays a part in regulating this pathway affecting how TGF-beta interacts with its receptors and consequently impacts Smad-dependent and independent signaling cascades. It is associated with other proteins like fibrillin-1 which contributes to the formation and maintenance of the extracellular microfibril structure supporting TGF-beta activation.
LTBP4 shows a strong connection to connective tissue disorders such as cutis laxa where mutations in LTBP4 result in skin elasticity issues. Additionally its function ties to pulmonary emphysema a condition characterized by tissue degeneration in the lungs partly due to compromised extracellular matrix integrity. LTBP4's interactions with proteins like elastin become critical in understanding these disease mechanisms given its role in elastic fiber assembly and maintenance.