Abcam, ab222849, Anti-TUBA1C antibody

Size: 50µL
Rabbit Polyclonal TUBA1C antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TUBA1C aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TUBA1C aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9BQE3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUBA1C also known as tubulin alpha-1C chain is a protein that functions as a component of microtubules which are integral parts of the cytoskeleton in eukaryotic cells. TUBA1C has a molecular mass of approximately 50 kDa. These proteins polymerize to form microtubules essential for various cellular processes such as axonal growth cell division and intracellular transport. TUBA1C is mainly expressed in brain tissues but can also be found in other organ systems indicating its role beyond neuronal function.
Biological function summary
The tubulin alpha-1C chain plays a significant role in stabilizing cellular structures and facilitating cell division by forming the mitotic spindle. It participates in forming a heterodimer with beta-tubulin a basic structural unit of microtubules. This heterodimer assembles into microtubule filaments which are critical for cell shape and transport mechanisms. TUBA1C as part of the microtubule network helps guide the signaling pathways that are important for neuron functionality and brain development.
Pathways
TUBA1C is an important player in the mitotic cell cycle and the intracellular transport pathway. It works closely with beta-tubulin to regulate the assembly and disassembly of microtubules which are important steps in cell division and transport within cells. Additionally TUBA1C interacts with MAPs (microtubule-associated proteins) which regulate the dynamics of microtubule systems impacting how cells react to environmental changes and signaling cues during the cell cycle.
Aberrant expression or dysfunction of TUBA1C has been linked to neurodevelopmental disorders and certain types of cancer. Disruption in TUBA1C function can lead to improper neuron migration resulting in conditions such as lissencephaly. Its involvement in cancer relates to its critical role in cell division where abnormal activity can contribute to uncontrolled proliferation. TUBA1C is often examined together with MAPs and other tubulin isoforms in studies related to these diseases to better understand their complex interactions and develop potential therapeutic interventions.