Abcam, ab223062, Anti-ZRSR2 antibody

Size: 50µL
Rabbit Polyclonal ZRSR2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZRSR2 aa 150-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZRSR2 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.Q15696

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZRSR2 (Zinc finger CCCH-type RNA-binding motif and serine/arginine-rich 2) plays a role in splicing influencing the splicing process of pre-mRNA by recognizing the 3' splice site. This protein weighs around 53 kDa and can be found in both the nucleus and cytoplasm of cells. Its expression occurs ubiquitously across various human tissues highlighting its foundational roles in cellular function.
Biological function summary
ZRSR2 is involved in regulating normal splicing via the recognition of U12-type introns. The protein is a part of the spliceosomal complex working closely with other spliceosomal components. This ensures accurate removal of these minor introns during the RNA processing phase. Mutations in ZRSR2 can lead to splicing errors which suggests its importance in gene expression.
Pathways
Splicing and gene expression are significant pathways involving ZRSR2. It is functionally connected to the spliceosomal complex and interacts with snRNP particles like U2AF2 and U2AF1. These interactions highlight ZRSR2's role as a critical player in post-transcriptional modification processes ensuring that genes are correctly expressed.
Malfunctions in ZRSR2 are linked to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). ZRSR2 mutations can result in an improper splicing of RNA contributing to these hematologic conditions. In the context of these diseases ZRSR2's interaction with related splicing factors such as SF3B1 further emphasizes the impact of defective splicing in the development and progression of these disorders.