Abcam, ab223085, Anti-hCNT3 antibody

Size: 50µg / 50µL
Rabbit Polyclonal hCNT3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC28A3 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC28A3 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9HAS3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Human concentrative nucleoside transporter 3 (hCNT3) also known as SLC28A3 is responsible for the active transport of nucleosides across the cellular membrane. It is a member of the concentrative nucleoside transporter family and functions as a symporter using sodium or proton gradients to transport substrates. The protein has a mass of approximately 76 kDa. Its expression occurs widely with higher levels seen in the small intestine liver kidney and pancreas where high nucleotide metabolism activity is required.
Biological function summary
Human concentrative nucleoside transporter 3 plays an important role in cellular uptake of nucleosides and nucleoside analog drugs. These substrates are necessary for nucleotide synthesis and DNA replication. hCNT3 is not known to be a part of a larger protein complex but collaborates closely with intracellular enzymes that process nucleotides. Its ability to transport therapeutic nucleoside analogs makes it significant in pharmacology particularly in the treatment of cancer and viral infections.
Pathways
Human concentrative nucleoside transporter 3 is an important component in nucleoside salvage pathways. This is important for nucleotide recycling within cells ensuring adequate supply of DNA and RNA precursors. hCNT3 also interacts functionally with other transporter proteins like hCNT1 and hCNT2 which handle different substrate specificities. This cooperation ensures a wide range of nucleosides are able to cross cell membranes demonstrating the integration of hCNT3 in broader nucleotide metabolic processes.
Human concentrative nucleoside transporter 3 has links to certain cancer types and genetic metabolic disorders. Its ability to uptake nucleoside analog drugs means it affects chemotherapeutic efficiency and resistance in cancers like leukemia. Also mutations in the gene encoding hCNT3 may lead to altered drug metabolism impacting treatment outcomes. The transporter's interaction with other transport proteins such as hENT1 can compound these effects since they may influence drug uptake and retention at cellular levels.