Abcam, ab223880, TTFA, Mitochondrial Complex II inhibitor

Size: 100mg / 500mg
MW 222.19 Da, Purity >98%. Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC 50 = 0.54 μM).
Key facts
CAS number:326-91-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:222.19 Da,
Molecular formula:C8H5F3O2S,
PubChem:5601,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,
Biochemical name:2-Thenoyltrifluoroacetone,
Biological description:Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).,
Canonical smiles:C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F,
InChi:InChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2,
InChiKey:TXBBUSUXYMIVOS-UHFFFAOYSA-N,
IUPAC Name:4,4,4-trifluoro-1-thiophen-2-ylbutane-1,3-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C