Abcam, ab224097, Anti-MOSC2 antibody

Size: 100µL
Rabbit Polyclonal MOSC2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTARC2 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTARC2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q969Z3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MOSC2 also known as CIAPIN1 or Mitochondrial amidoxime reducing component 2 is a protein encoded by the MOSC2 gene. This protein has a molecular weight of approximately 38 kDa. Mechanically MOSC2 acts as an oxidoreductase facilitating electron transfer across various substrates. MOSC2 is expressed in multiple tissues with higher expression observed in liver kidney and heart which suggests its diverse functional roles in different physiological contexts.
Biological function summary
MOSC2 is part of a mitochondrial complex involved in metabolic processes. It plays a role in catalyzing the reduction of N-hydroxylated substrates linking electron transfer to cellular metabolism. The protein assists in the activation of pro-drugs by reducing N-hydroxylated intermediates. This function positions MOSC2 as a significant player in cellular metabolic pathways showcasing its involvement in the broader scheme of mitochondrial function and energy homeostasis.
Pathways
MOSC2 participates in detoxification and mitochondrial respiratory pathways which are essential for maintaining cellular health. It plays a role in the mitochondrial amidoxime reducing component (mARC) pathway where it collaborates with cytochrome b5 and NADH cytochrome b5 reductase for electron transfer. This interaction highlights its necessity for redox reactions confirming its importance in maintaining the balance of reactive molecules within the cell.
MOSC2 has been implicated in metabolic disorders and certain cancers. Alterations in MOSC2 function or expression can affect mitochondrial metabolism potentially contributing to metabolic syndrome. Additionally its interactions with proteins such as NADH cytochrome b5 reductase can influence cancer cell metabolism suggesting a role in tumorigenesis. These associations highlight its potential as a therapeutic target in conditions where metabolic pathways are disrupted.