Abcam, ab224320, Anti-TIMM9 antibody

Size: 100µL
Rabbit Polyclonal TIMM9 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TIMM9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TIMM9.Q9Y5J7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIMM9 also known as TINY TIM9 or TIM9 is a part of the TIMM complex that plays an essential role in mitochondrial protein import. It is a small protein with a molecular mass of approximately 10 kDa. TIMM9 is expressed mainly in mitochondria and is involved in the important process of transferring precursor proteins from the TOM complex to the TIM22 translocase within the inner mitochondrial membrane. This transfer ensures that proteins are correctly integrated and functional within the mitochondrial inner membrane.
Biological function summary
TIMM9 operates as part of the TIMM9-TIMM10 complex which is integral for the import and assembly of mitochondrial carrier proteins. This assembly occurs within the mitochondrial intermembrane space aiding in the continuation of oxidative phosphorylation and energy production by maintaining the mitochondrial carrier proteins’ activity. The TIMM9-TIMM10 complex therefore facilitates the stability and functionality of mitochondrial membranes important for cellular metabolism and energy homeostasis.
Pathways
TIMM9 is significantly involved in the protein translocation pathway specific to mitochondria. It functions closely with the TIM22 translocase serving as an escort for protein precursors. In this pathway TIMM9 collaborates alongside TIMM10 forming an essential step in the translocation of hydrophobic precursor proteins important for mitochondrial activity. This collaboration ensures the integrity of importing key proteins that drive processes like ATP production and metabolic regulation within mitochondria.
Mutations or dysfunctions in TIMM9 are linked to mitochondrial disorders that affect energy metabolism. Disorders such as Mitochondrial Encephalomyopathy can arise from a deficiency in the TIMM9-TIMM10 functional complex causing impaired protein import and oxidative phosphorylation. TIMM9 is also interconnected with disorders involving TIMM10 since they jointly facilitate mitochondrial function indicating that disruptions in either protein can lead to related pathophysiological conditions where energy metabolizing tissues like those in the brain and muscles are most affected.