Abcam, ab226201, Anti-GRIP1 antibody

Size: 100µL
Rabbit Polyclonal GRIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GRIP1 aa 1000-1100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GRIP1 aa 1000-1100. The exact immunogen used to generate this antibody is proprietary information.Q9Y3R0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226201 was affinity purified using an epitope specific to GRIP1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRIP1 also known as Glutamate Receptor Interacting Protein 1 is a protein that serves as a scaffold for various cellular signaling molecules. It weighs approximately 127 kDa. GRIP1 is expressed mainly in the central nervous system where it interacts with membrane proteins to facilitate their proper localization and function. It supports the clustering and stabilization of AMPA receptors at synaptic sites which is essential for synaptic transmission and plasticity.
Biological function summary
GRIP1 plays a role in synaptic formation and maintenance. It is a part of a multi-protein complex that influences the trafficking and stabilization of AMPA-type glutamate receptors. By regulating these receptors it contributes to synaptic plasticity a process fundamental for learning and memory. Additionally GRIP1 interacts with proteins like GRASP and liprin-α which further regulate synaptic density and neural connectivity.
Pathways
GRIP1 is involved in synaptic signaling pathways and neuronal communication. It participates in the maintenance of long-term potentiation (LTP) an activity-dependent strengthening of synapses that is central to memory and learning. GRIP1 interacts closely with proteins like GRASP1 and PICK1 in these pathways. These interactions are critical for mediating changes in synaptic strength and receptor turnover that underpin neural plasticity.
GRIP1's dysregulation associates with neuropsychiatric conditions such as autism spectrum disorder (ASD) and schizophrenia. Alterations in GRIP1 function can affect AMPA receptor trafficking impacting synaptic efficiency and cognitive function. In ASD GRIP1 connects with the protein SHANK3 influencing synapse functionality and neuronal development. In schizophrenia irregularities in GRIP1 contribute to synaptic dysfunction linking it to a broader network of proteins impacting glutamate signaling.