Abcam, ab226931, Anti-ATG2A antibody

Size: 100µL
Rabbit Polyclonal ATG2A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATG2A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATG2A. The exact immunogen used to generate this antibody is proprietary information.Q2TAZ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATG2A also known as Autophagy-related protein 2 homolog A is an important protein involved in autophagy. It has a molecular mass of approximately 230 kDa and is expressed in tissues like the liver heart and skeletal muscle. Mechanically ATG2A is important for the lipid transfer between membranes which is essential for the expansion of autophagosomes cellular structures that engulf and degrade damaged cellular materials.
Biological function summary
ATG2A plays an important role in macroautophagy by forming part of a multiprotein complex called the ATG9 complex. It participates in membrane tethering and expansion during autophagosome formation. This protein interacts with other autophagy-related proteins including the ATG8 family to facilitate the progression of the autophagic process thereby maintaining cellular health and homeostasis.
Pathways
ATG2A operates mainly within the autophagy pathway specifically the PI3K-AKT-mTOR signaling pathway which is vital for cellular survival and growth. In this context ATG2A acts in concert with proteins like ULK1 which helps initiate autophagy. The regulation of autophagic flux via ATG2A is critical for responding to cellular stress and adjusting metabolic activities according to the environmental conditions.
Mutations or dysfunction in ATG2A can impact cancer and neurodegenerative disorders such as Alzheimer's disease. The protein's role in cancer links to its association with protein components like Beclin 1 which regulates autophagic vacuole formation and influences cancer cell survival. In Alzheimer's disease ATG2A interactions with neural proteins can affect the degradation of misfolded proteins which is instrumental in disease progression.