Abcam, ab227213, Anti-WWP1 antibody

Size: 100µL
Rabbit Polyclonal WWP1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WWP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human WWP1. The exact immunogen used to generate this antibody is proprietary information.Q9H0M0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WWP1 also known as NEDD4-like E3 ubiquitin-protein ligase operates as an E3 ubiquitin ligase. This protein adds ubiquitin to target substrates marking them for degradation by the proteasome. WWP1 has a molecular mass of approximately 99 kDa. It is expressed in various tissues including the brain heart and skeletal muscles contributing to various cellular processes through its enzymatic activity.
Biological function summary
This protein controls multiple cellular functions by targeting specific proteins for ubiquitination. WWP1 remains an important regulator in cell growth differentiation and immune response. It often acts within protein complexes and associates with multiple substrates and partners. These interactions allow it to control the stability and activity of proteins impacting cellular homeostasis.
Pathways
The ubiquitin-proteasome pathway features WWP1 prominently especially modulating cell cycle regulation and apoptosis. WWP1 also interacts within the TGF-beta signaling pathway impacting cell growth and differentiation. Through these pathways it connects with proteins such as SMAD2/3 and PTEN influencing critical cellular events and signaling processes.
Abnormal WWP1 activity links to cancer and neurodegenerative diseases. In cancer particularly breast and prostate cancer WWP1 can influence tumor growth due to its interactions with proteins like p53 and PTEN. For neurodegenerative diseases impaired WWP1 function affects protein aggregation and degradation contributing to diseases like Alzheimer's where it interacts with amyloid precursor protein (APP).