Abcam, ab228451, Anti-Folate Receptor 4 antibody [TH6]

Size: 100µg
Rat Monoclonal Folate Receptor 4 antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing Izumo1r protein.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:TH6,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Tissue preparation containing Izumo1r protein. The exact immunogen used to generate this antibody is proprietary information.Q9EQF4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from TCS., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Folate Receptor 4 (FR4) also known as delta folate receptor is involved in the high-affinity binding and transport of folate and folate analogs across the cell membrane. Folate is an essential vitamin B9 derivative which cells use for important functions like DNA synthesis and repair. FR4 has a mass of approximately 30 kilodaltons. Researchers have found this receptor mainly on the surface of activated T cells which play an important role in the immune system.
Biological function summary
FR4 aids in the uptake of folate compounds necessary for cellular proliferation and survival. It is not generally part of a larger protein complex but it competes with other folate receptors like folate receptor alpha for binding to available folate molecules. The receptor’s function directly supports T cell activity and survival impacting immune responses.
Pathways
The folate receptor FR4 contributes to immune response pathways by ensuring an adequate supply of folate for T cells. It is a part of the broader folate metabolism pathway which also involves proteins such as dihydrofolate reductase (DHFR) that further process folate for nucleic acid synthesis. This participation in folate metabolism supports not only primary cellular functions but also the specialized activity of immune cells.
FR4 is notably associated with autoimmune diseases such as rheumatoid arthritis where abnormal expression levels have been observed in T cells. Also FR4 connects indirectly to cancer as altered folate metabolism can contribute to oncogenesis. Although it functions separately from proteins like thymidylate synthase which is directly involved in cancer proliferation both are part of the overall metabolic pathways impacting disease progression.