Abcam, ab229143, Anti-NTAQ1 antibody

Size: 100µL
Rabbit Polyclonal NTAQ1 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NTAQ1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NTAQ1. The exact immunogen used to generate this antibody is proprietary information.Q96HA8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NTAQ1 also known as N-terminal amidation transferase Q1 is a protein involved in the modification of peptide termini. The protein facilitates the process of amidation at the N-terminus of target peptides. NTAQ1 has a molecular mass of approximately 35 kDa and is found mainly in the cytoplasm of various human tissues. It displays higher expression levels in tissues such as liver and kidney where peptide maturation processes are highly active.
Biological function summary
NTAQ1 contributes to the stability and functionality of peptides by mediating their amidation. Through this modification peptides often gain increased resistance to degradation and enhanced affinity for their receptors. NTAQ1 operates as part of the enzyme complex involved in post-translational modifications interfacing with other maturation enzymes. Its role enhances the biological activity of neuropeptides and hormones influencing numerous physiological processes.
Pathways
NTAQ1 participates in metabolic and signaling pathways involving peptides and proteins. It takes part in the peptide processing pathway interacting with several proteolytic enzymes. Furthermore NTAQ1's activity integrates into the signaling pathway of neuropeptides working in association with proteins like those from the endopeptidase family which regulate neurotransmitter release.
NTAQ1's function connects to ailments where peptide regulation is disturbed. Its involvement with peptide hormones links it to metabolic disorders like obesity given the role of these peptides in energy regulation. Additionally NTAQ1 may relate to some neurological disorders through its modification of neuropeptides which are implicated in conditions such as Alzheimer's disease. The protein interacts with affected proteins such as amyloid-beta precursor protein highlighting its potential impact on disease progression.